PAE has helped numerous men who suffer from Benign Prostatic Hyperplasia (BPH)

Listen to their stories and discover how PAE treatment may help you.

Reclaiming Quality of Life with Prostatic Artery Embolization

Written by Alicia Armeli and Laurie Birdsong

“The difference is like night and day.” This is how Larry Sago describes his life before and after prostatic artery embolization (PAE).

Larry’s journey began when he was diagnosed with an enlarged prostate, also known as Benign Prostatic Hyperplasia (BPH). A common condition, about half of all men in their 50s develop BPH—a statistic that increases with age.1 Although non-cancerous, BPH can cause a host of bothersome urinary symptoms, including feelings of urinary urgency, weak or interrupted urine stream, and urinary frequency.

For months prior to undergoing PAE, BPH began to take a major toll on Larry’s life. He started experiencing urine retention and found at times he couldn’t go at all. In pain, Larry resorted to driving himself to the ER to get a Foley catheter inserted to temporarily relieve the pressure.

For many men like Larry who suffer from BPH, the first line of treatment is commonly prescription medications to treat the symptoms, but these are occasionally ineffective and often have less-than-desirable side effects. After trying medications, Larry found his symptoms couldn’t be controlled any longer and continued to worsen. “My urologist told me TURP [Transurethral Resection of the Prostate] was about the only answer.”

TURP is a surgical procedure that cuts away the prostate tissue that blocks the flow of urine. While very effective in improving urination, it can be associated with complications like bleeding, urinary leakage and sexual side effects. The bleeding risks become more concerning the larger the prostate becomes.

Not wanting to have surgery or to risk having the complications associated with TURP, Larry researched non-surgical treatment options online but wasn’t finding much. As luck would have it, Larry one day found an article by University of North Carolina (UNC) Clinical Assistant Professor of Radiology Dr. Ari Isaacson discussing minimally invasive PAE at the UNC Health Care System’s Center for Heart and Vascular Care.

“I emailed Dr. Isaacson as soon as I read about [PAE],” Larry recalls. “Amazingly, within half an hour he’d written me back asking for my phone number to further talk about the procedure. He called me and communicated all aspects of [PAE] very clearly.” Liking what he heard, Larry drove from Atlanta to Chapel Hill to meet with Dr. Isaacson. Once a biopsy cleared him of prostate cancer, Larry was able to undergo the procedure as part of a clinical trial.

PAE is performed by an interventional radiologist and takes approximately one to two hours to complete. Under conscious sedation, a small puncture is made in the upper thigh or arm. A slender catheter is then inserted and guided via real-time imaging into the prostatic arteries that supply the prostate with blood. Tiny embolic particles are injected into these arteries, blocking blood flow to the enlarged areas of the prostate. Once deprived of blood, these areas of tissue die (necrosis).

“PAE results in shrinking and softening of the prostate which allows for urine to flow through easier, ultimately reducing urinary symptoms,” Dr. Isaacson explains. “Some of the advantages of PAE are that it is performed as an outpatient procedure and the recovery time is quick. In most cases, no Foley catheter is required. PAE also has very little chance of affecting sexual function. In some cases, sexual function is even improved after patients are able to stop taking BPH medications”

Post-PAE, Larry describes the procedure as easy with no pain or bleeding. Afterward, he was able to go back to his hotel room in Chapel Hill, spend the night, and drive home to Atlanta the next day. “For about a week, my former BPH symptoms returned, but they were briefer and milder this time. Once they went away, I felt like I was 20 years old again!”

PAE not only resulted in clinical improvements. It also gave Larry something priceless—his life back.

“I literally don’t think about the symptoms I used to struggle with,” Larry says. “I can go play golf without having to worry about going to the bathroom in the middle of the golf course!”

“I’m so pleased for Larry,” Dr. Isaacson notes. “His case demonstrates how effective this procedure can be. Many PAE patients can enjoy improved urination for years following the procedure.”

Feeling truly fortunate to have been a candidate for PAE, Larry says the only thing he would’ve done differently was have the procedure sooner. “If this treatment had been available, I would’ve done it years earlier. I simply hope there’s more awareness so that others can experience the boost in quality of life and long-term health that I did.”

ABOUT THE DOCTOR Ari J. Isaacson, MD, is a Clinical Physician at the UNC Health Care System’s Center for Heart and Vascular Care , Clinical Assistant Professor of Vascular and Interventional Radiology, and Co-Director of Clinical Research for Radiology at the UNC School of Medicine in Chapel Hill, NC.

Dr. Isaacson’s clinical interests include arterial embolization, interventional oncology, and vascular imaging. In addition to leading PAE research, he’s currently the principal investigator for a clinical trial studying geniculate artery embolization (GAE) for the treatment of knee pain and has received several grants to study novel treatments for liver cancer. Dr. Isaacson also enjoys mentoring students and residents and is the faculty advisor for the UNC School of Medicine Interventional Radiology Interest Group.


  1. Urology Care Foundation. (n.d.). What Is Benign Prostatic Hyperplasia (BPH)?. Retrieved from

Meet Ron

“Not being able to go to the bathroom? It’s a big part of life. You don’t realize it until you can’t do it,” says Ron, who suffered from symptomatic BPH. As an avid Harley rider, Ron’s long rides became too painful due to his condition. As his prostate continued to grow, the medication he had been taking no longer helped, which led him to PAE.

For Ron, the PAE procedure took 90 minutes and he was home the next day.

Ron even planned a 10,000 mile ride the following summer.

Post-procedure, Ron says, “Any man that can have the PAE over any other procedure, it’s absolutely a no-brainer. You just have to go for it.”

For more information, watch his story.

Michel’s Testimonial

For more than 10 years, Michel took medication to help with his lower urinary tract symptoms (LUTS). But as his condition became more complicated, surgery was suggested, which Michel did not want. Instead, he chose PAE.

Ten days after PAE, Michel describes feeling like a young man again.

His first presentation back at work lasted 3 hours in front of 350 associates, without any urgent need to urinate.

View more about his progress.

Bill’s Story

After taking medicine for years for his symptomatic BPH, Bill felt out of his mind. He remembers the day his symptoms got unbearably worse, causing him to be in extreme pain for 4 hours, leading to a trip to the emergency room. Bill decided he never wanted to experience that again, and his determination led him to learn about minimally-invasive PAE.

After PAE? Bill describes his results as remarkable.

Watch Bill’s full story.

Is PAE right for you?

Learn more about BPH and talk to your doctor to see if PAE treatment is right for you.